Capecitabine Medications

Capecitabine is an orally administered fluoropyrimidine carbamate that acts as a cytotoxic agent against tumour cells. It is primarily used to treat breast, gastric, and colorectal cancers. As a critical component in oncology care, it is available in several high-quality generic versions. Our pharmacy ensures you can access authentic treatments containing Capecitabine through a secure and professional service.

Xeloda

Oncology Support

500mg

21.11 / tablet
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Capnat

Oncology Support

500mg

2.98 / tablet
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Capecitabine

Oncology Support

500mg

2.98 / tablet
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Capecitabine Info

What Is Capecitabine?

Capecitabine is a chemotherapy medicine that belongs to the class of oral antimetabolites. It works inside the body to stop cancer cells from growing and spreading. The drug is taken by mouth and is found in several brand-name and generic products sold in the United Kingdom, including Xeloda, Capnat and plain-label capecitabine tablets.

Medications That Contain Capecitabine

In the UK, capecitabine is available as:

  • Xeloda - the original brand, supplied in tablets of 125 mg, 250 mg and 500 mg.
  • Capnat - a generic version that matches the strength and formulation of Xeloda.
  • Capecitabine - other generic tablets marketed by different manufacturers, often identical in appearance and dosage.

All of these products come in oral tablet form, and they are usually prescribed in cycles that last several weeks, followed by a rest period. The exact strength and schedule depend on the individual medication and the condition being treated, so patients should always follow the information that comes with their specific prescription.

What Does Capecitabine Treat?

Capecitabine is used primarily for cancers that respond to a drug called 5-fluorouracil (5-FU). In the UK it is approved for:

  • Colorectal cancer - particularly when the disease has spread or returned after surgery.
  • Breast cancer - often given together with other chemotherapy agents for advanced disease.
  • Gastric (stomach) cancer - used after surgery or in combination with other treatments.
  • Head and neck cancers - sometimes part of a combined regimen for tumours in the mouth, throat or voice box.

The medication is usually given to adults whose cancer is not curable with surgery alone, aiming to slow tumour growth, relieve symptoms and improve quality of life. Some clinicians may also prescribe capecitabine for other tumour types based on emerging evidence, but those uses are considered off-label.

How Capecitabine Works

Capecitabine is a pro-drug, meaning it is inactive until the body changes it into the active form, 5-FU. This conversion mainly occurs inside cancer cells, where enzymes are more abundant than in normal tissue. Once turned into 5-FU, the drug disrupts the cancer cells’ ability to copy DNA, which stops them from dividing and eventually leads to cell death. Because the activation happens mostly within tumours, capecitabine tends to cause fewer side effects than an intravenous 5-FU injection, although some side effects are still common.

Safety Information

Common Side Effects

People taking capecitabine often notice mild, temporary effects such as:

  • Nausea or loss of appetite.
  • Tiredness and general weakness.
  • Diarrhoea or loose stools.
  • Skin changes on the palms of the hands and soles of the feet (known as “hand-foot syndrome”).
  • Low red-blood-cell counts, which can cause mild anaemia.

These reactions usually lessen when the treatment cycle ends or with simple supportive measures.

Serious Reactions

Although rare, some reactions require urgent medical attention:

  • Severe allergic signs such as swelling of the face, lips or tongue, or difficulty breathing.
  • Very low white-blood-cell or platelet counts, which can increase infection risk or cause unusual bruising.
  • Persistent vomiting, high fever, or severe diarrhoea that leads to dehydration.

If any of these signs develop, seek help from a healthcare professional without delay.

Who Should Be Cautious

Capecitabine should be used with care in certain situations:

  • Pregnancy and breastfeeding - the drug can harm an unborn baby and is not safe for nursing infants.
  • Liver or kidney problems - reduced organ function can cause the medicine to build up in the body.
  • Allergy to fluoropyrimidines - a known hypersensitivity to 5-FU or similar drugs means capecitabine should be avoided.

Patients with these conditions must discuss alternatives with their specialist.

Interaction Awareness

Capecitabine can interact with other substances, so patients should be aware of general categories:

  • Other chemotherapy agents - combining drugs may increase toxicity.
  • Anticoagulants such as warfarin - may enhance blood-thinning effects.
  • Alcohol - excessive intake can worsen liver strain and increase side-effect risk.

Because each medication containing capecitabine may have its own interaction list, readers should refer to the specific product information for full details.

What to Know Before Using

Store tablets in a dry place below 30 °C and keep them out of reach of children. Treatment often follows a pattern of several weeks on medication followed by a rest period, but the exact schedule varies between Xeloda, Capnat and other generic forms. Always read the patient leaflet that comes with your medication and follow the directions on the label.

For detailed usage, dosing, administration, refer to your specific medication's information.

Information Disclaimer

This article offers general educational information about capecitabine as an active substance used in various medicines. Its purpose is to help patients better understand the ingredient and the conditions it is used to treat. It is not a substitute for professional medical advice or for the specific instructions provided with individual products. Medicines containing capecitabine may differ in formulation, strength, and directions for use. Always consult the labeling of your particular medication and follow your healthcare provider’s guidance for complete information on proper use, dosage, and safety.

Information regarding Capecitabine is compiled from recognised clinical guides and reviewed periodically. This is for general reference; always check with a doctor or healthcare provider before starting any treatment.
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