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Avana

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Avana (avanafil) is a fast-acting PDE5 inhibitor indicated for the treatment of erectile dysfunction. It works by relaxing the smooth muscles and increasing blood flow to the male genital area. Avana is often selected for its rapid onset of action, helping adult men restore sexual function effectively.


Ingredient
Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Avanafil
Reference Brand
Spedra
Manufacturer
Sunrise Remedies
Product Form
Tablet
Regulatory Classification
Rx
Primary Category
Sexual Health
Product Category
Genito-urinary system, Drugs used in erectile dysfunction
Pharmacological Class
PDE5 Inhibitor
Clinical Indications
Manufacturer Description
A rapid-acting medication for men with erectile dysfunction, designed to work as quickly as 15 minutes.
Mechanism of Action
Avanafil increases blood flow to the penis during sexual stimulation. It acts more quickly than many other similar medications in its class.
Route of Administration
Oral
Onset Time
15-30 minutes
Duration
Up to 6 hours
Contraindications
Severe kidney or liver disease, Uncontrolled blood pressure, Use of nitrates
Severe Adverse Events
Sudden decrease in vision, Hearing impairment, Priapism
Common Side Effects
Headache, Flushing
Uncommon Side Effects
Nasal congestion, Back pain
Drug Interactions
Ketoconazole, Ritonavir, Nitrates, Grapefruit juice
Pregnancy Safety Warnings
Not for use in women.
Age Restrictions
18 years and older
Storage Guidelines
Store at room temperature in original packaging.
Related Products
Spedra, Viagra, Cialis

Avana FAQ

Can Avana be taken with food?

Yes. Avana can be taken with or without food. A high-fat meal may slightly delay the onset of action, but it does not reduce overall effectiveness.

What is the difference between Avana and other ED pills like Viagra?

Avanafil (Avana) has a faster onset, often within 15 minutes, compared with sildenafil (Viagra), which typically requires 30-60 minutes. All three are PDE5 inhibitors, but they differ in chemical structure, dosing flexibility, and side-effect profiles.

Is a prescription required for Avana in the UK?

Yes. Avana is a prescription-only medication regulated by the MHRA. It cannot be obtained over the counter.

How long does the effect of a 100 mg dose last?

The therapeutic effect generally lasts up to 6 hours, though individual response may vary.

Can I take Avana if I have high blood pressure?

Avana can be used by men with controlled hypertension, but blood pressure should be stable before starting therapy. Uncontrolled high blood pressure is a contraindication.

What should I do if I experience a painful erection lasting more than 4 hours?

Seek emergency medical care immediately. This condition, called priapism, requires prompt treatment to prevent permanent damage.

Are there any pill imprint codes that identify Avana tablets?

Avana tablets are commonly imprinted with “AVANA XX,” where “XX” denotes the strength (e.g., “AVANA 50”). Verify the imprint with the dispensing pharmacy.

Will avanafil show up on a drug test for employment or sports?

Avanafil is not typically screened for in standard workplace drug tests. However, some sports anti-doping agencies may include PDE5 inhibitors in their testing panels.

Can I take Avana if I am on a medication for prostate enlargement?

Alpha-blockers used for benign prostatic hyperplasia (e.g., tamsulosin) can be taken with avanafil, but starting at the lowest avana dose and monitoring blood pressure is advisable.

What is the typical cost difference between brand Avana and generic avanafil?

Brand-name avana products are usually priced higher than generic avanafil tablets of equivalent strength. Pricing varies by pharmacy and NHS prescribing policies.

What is Avana?

Avana is a prescription medication that contains avanafil as its active ingredient. It belongs to the phosphodiesterase-5 (PDE5) inhibitor class and is used to treat erectile dysfunction (ED) in adult men. In the United Kingdom, avanafil is regulated by the Medicines and Healthcare products Regulatory Agency (MHRA) and is available only with a prescription. The medication is supplied as a pill in strengths of 50 mg, 100 mg, and 200 mg.

How Avana Works in the Body

Avanafil inhibits the enzyme phosphodiesterase-5, which normally breaks down cyclic guanosine monophosphate (cGMP) in the smooth muscle of the penis. By blocking PDE5, avanafil allows cGMP to accumulate, leading to relaxation of the smooth muscle and increased blood flow during sexual stimulation.

  • Onset of action: Effects can be felt as early as 15 minutes after ingestion.
  • Peak effect: Usually occurs 30-60 minutes after the dose.
  • Duration: Efficacy typically lasts up to 6 hours, depending on the dose and individual response.

Because avanafil’s activity is tied to sexual arousal, it does not cause an erection without stimulation.

Conditions Treated by Avana

Avana is approved in the UK for the treatment of erectile dysfunction in adult men. The medication is indicated for men who experience difficulty achieving or maintaining an erection sufficient for satisfactory sexual activity. It is not approved for use in women, children, or for any condition other than erectile dysfunction.

Patient Suitability and Contraindications

Who Should Use Avana?

  • Adult men diagnosed with erectile dysfunction who are able to become sexually aroused.
  • Patients whose cardiovascular status allows sexual activity, as assessed by a healthcare professional.

Absolute Contraindications

  • Known hypersensitivity to avanafil or any tablet excipient.
  • Concurrent use of nitrates (e.g., nitroglycerin, isosorbide dinitrate) in any form.
  • Severe uncontrolled hypertension (systolic > 180 mmHg or diastolic > 120 mmHg).
  • Recent (within 6 weeks) history of myocardial infarction, stroke, or life-threatening arrhythmia.

Relative Contraindications / Cautions

  • Use of alpha-blockers (e.g., tamsulosin) - dose adjustment may be needed.
  • Significant hepatic impairment (Child-Pugh Class C).
  • Renal impairment (eGFR < 30 mL/min/1.73 m²) - consider lower starting dose.
  • History of non-arteritic anterior ischemic optic neuropathy (NAION).

Special Populations

  • Pregnancy & lactation: Not applicable; avanafil is not indicated for women.
  • Elderly: No dose reduction is required solely based on age, but comorbidities and concomitant drugs should be reviewed.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Headache - frequently reported, usually mild.
  • Flushing - warm sensation, often transient.
  • Nasal congestion - mild stuffiness.
  • Back pain - occasional, resolves without treatment.

These effects are generally mild and may lessen with continued therapy.

Serious Adverse Events

  • Sudden vision loss (possible NAION) - seek immediate medical attention.
  • Sudden hearing loss - urgent evaluation required.
  • Priapism (erection lasting > 4 hours) - treat as an emergency to prevent tissue damage.

Drug Interactions

  • Major: Concurrent nitrates (including recreational nitroglycerin) can cause profound hypotension.
  • Moderate:
  • CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir) may increase avanafil plasma levels; dose reduction may be required.
  • CYP3A4 inducers (e.g., rifampin, carbamazepine) can lower effectiveness.
  • Alpha-blockers - risk of additive blood-pressure lowering; start with the lowest avanafil dose.

Patients should provide a complete medication list, including over-the-counter products and herbal supplements, before starting avana.

Food and Lifestyle Interactions

  • Food: Avanafil can be taken with or without food. A high-fat meal may slightly delay onset but does not diminish overall efficacy.
  • Alcohol: Moderate alcohol consumption does not significantly affect avanafil, but excess alcohol can impair sexual performance and increase the risk of hypotension.
  • Driving: No impairment of mental or motor skills has been reported; however, patients experiencing dizziness should avoid operating machinery until symptoms resolve.

How to Take Avana

  • Standard dosing:
  • Initial dose: 100 mg taken as needed, about 15-30 minutes before anticipated sexual activity.
  • Alternative starting doses: 50 mg for men cautious about side effects, or 200 mg for men who have not responded to lower doses.
  • Maximum recommended dose: 200 mg in a 24-hour period.
  • Frequency: Not to be used more than once per day.

Special Population Adjustments

  • Renal or hepatic impairment: Consider starting at 50 mg; titrate based on tolerance and efficacy.
  • Elderly patients with comorbidities: Initiate with 50 mg to assess tolerability.

Administration Guidance

  • Swallow the pill whole with a glass of water.
  • Do not crush, chew, or split the tablet unless a specific formulation (e.g., scored tablet) indicates it is permissible.
  • Store at room temperature, away from moisture and direct sunlight.

Missed Dose

  • Avana is taken as needed, not on a fixed schedule. If a dose is missed and sexual activity is no longer anticipated, simply skip that dose-do not double the next dose.

Overdose

  • Symptoms may include severe hypotension, prolonged erection, or syncope.
  • Seek immediate medical assistance; treatment is supportive (e.g., intravenous fluids, vasopressors) as no specific antidote exists.

Discontinuation

  • Avana does not require tapering; it can be stopped abruptly when no longer needed.
  • If discontinuation follows long-term use, no withdrawal syndrome is expected.

Monitoring and Follow-Up

  • Blood pressure: Check before initiating therapy and periodically, especially in patients with hypertension.
  • Cardiovascular assessment: Patients with known heart disease should have a recent cardiac evaluation to confirm that sexual activity is safe.
  • Adverse-event review: Any occurrence of priapism, vision changes, or hearing loss warrants immediate clinical review.

Routine laboratory monitoring is not required for avanafil itself, but standard health checks for men with erectile dysfunction (lipid profile, glucose, testosterone) may be advisable.

Storage and Handling

  • Keep tablets in the original container, tightly closed, and out of reach of children.
  • Store at 15-30 °C, protected from excess moisture.
  • Do not use tablets past the expiry date printed on the package.

Medication-Specific Glossary

Phosphodiesterase-5 (PDE5) inhibitor
A drug class that blocks the PDE5 enzyme, preventing the breakdown of cGMP and promoting penile blood flow during sexual stimulation.
cGMP (cyclic guanosine monophosphate)
A intracellular messenger that induces smooth-muscle relaxation in the corpus cavernosa, facilitating erection.
Half-life
The time required for the plasma concentration of a drug to decrease by 50 %; avanafil’s half-life is approximately 5 hours.
Contraindication
A specific situation where a drug should not be used because the risk of harm outweighs any potential benefit.
Priapism
A prolonged, painful erection lasting > 4 hours that can lead to permanent tissue damage if not treated promptly.

Medical Disclaimer

This article provides educational information about Avana and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Avana is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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