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Caverta

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Caverta (sildenafil) is a phosphodiesterase type 5 inhibitor used to treat erectile dysfunction in men. It aids adults by increasing blood flow to specific areas of the body during physical arousal. By relaxing smooth muscle tissues, it helps achieve and maintain a firm response required for activity.


Ingredient
Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Sildenafil
Reference Brand
Sildenafil
Manufacturer
Sun Pharma
Product Form
Tablet
Regulatory Classification
Rx
Primary Category
Erectile Dysfunction Treatment
Product Category
Urologicals, Drugs used in erectile dysfunction
Pharmacological Class
PDE5 Inhibitor
Clinical Indications
Manufacturer Description
A common treatment for men with erectile dysfunction, helping to restore sexual function when needed.
Mechanism of Action
It works by relaxing the blood vessels in the penis, allowing more blood to flow into it when sexually excited. This helps to achieve and maintain a firm erection.
Route of Administration
Oral
Onset Time
30-60 minutes
Duration
4-6 hours
Contraindications
Nitrate medication use, Severe heart problems, Recent stroke or heart attack, Loss of vision due to NAION
Severe Adverse Events
Prism (erection lasting over 4 hours), Sudden vision loss, Chest pain, Fainting
Common Side Effects
Headache, Flushing, Indigestion
Uncommon Side Effects
Nasal congestion, Dizziness, Visual colour tinge
Drug Interactions
Nitroglycerin, Isosorbide, Alpha-blockers, Ritonavir
Pregnancy Safety Warnings
Not indicated for use in women.
Age Restrictions
Not for use by children or those under 18.
Storage Guidelines
Store at room temperature in original packaging.
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Caverta FAQ

Can I take Caverta with alcohol?

Moderate alcohol consumption is generally tolerated, but excessive drinking can increase the risk of dizziness, hypotension, and reduced erectile response. For optimal effectiveness, limit alcohol intake around the time you plan to take the medication.

What does the Caverta tablet look like?

Caverta tablets are round, film-coated, and typically bear a distinct imprint indicating the dose strength (e.g., “C 50” for 50 mg and “C 100” for 100 mg). Inactive ingredients may include lactose, magnesium stearate, and microcrystalline cellulose. Regional packaging variations can occur.

Will Caverta show up on a drug test for work or sport?

Standard employment drug screens do not test for sildenafil. However, sport governing bodies may include PDE5 inhibitors on prohibited substance lists for certain disciplines; athletes should verify the specific anti-doping regulations applicable to their sport.

Is Caverta safe for men with high blood pressure?

Men with well-controlled hypertension can often use sildenafil safely, but uncontrolled blood pressure (> 180/110 mmHg) is a relative contraindication. The prescribing clinician should evaluate cardiovascular status before initiating therapy.

Can I travel internationally with Caverta?

Yes, provided you carry a valid prescription and the original packaging. Some countries may require a customs declaration for prescription medicines; check the destination’s import regulations in advance.

How does Caverta compare with other ED treatments like tadalafil?

Both are PDE5 inhibitors, but tadalafil has a longer half-life (up to 36 hours) and may be taken daily at a low dose. Caverta (sildenafil) has a shorter duration of action, which can be advantageous for on-demand use. Choice depends on patient preference, response, and side-effect profile.

What are the inactive ingredients, and can they cause allergies?

Common excipients in Caverta tablets include lactose, magnesium stearate, and silicon dioxide. Individuals with lactose intolerance or specific excipient allergies should discuss alternatives with their pharmacist.

Do I need to store Caverta in a special container?

A standard prescription bottle with a child-proof cap is sufficient. Keep the medication away from heat and humidity, and avoid storing it in bathrooms or car trunks.

When will generic sildenafil become available in the UK?

Sildenafil’s patent expiry in the UK occurred in 2021, and several generic manufacturers now market the drug under its chemical name. Prices and availability may vary, but the therapeutic effect remains equivalent to the branded product.

Is there a risk of dependence or addiction to Caverta?

Sildenafil does not produce physiological dependence. Psychological reliance can develop in some individuals who fear erectile difficulties without the medication; counseling and open communication with a partner or clinician can help manage such concerns.

What is Caverta?

Caverta is a prescription-only medication (POM) marketed in the United Kingdom for the treatment of erectile dysfunction (ED). Its sole active ingredient is sildenafil, a phosphodiesterase-type 5 (PDE5) inhibitor. Available as a swallowed pill, Caverta is supplied in strengths of 50 mg and 100 mg. The drug is regulated by the UK Medicines and Healthcare products Regulatory Agency (MHRA) and must be prescribed by a qualified healthcare professional.

How Caverta Works in the Body

Sildenafil belongs to the PDE5 inhibitor class. In men with erectile dysfunction, the natural sexual response triggers the release of nitric oxide in the corpus cavernosum. Nitric oxide stimulates the production of cyclic guanosine monophosphate (cGMP), which relaxes smooth muscle and allows increased blood flow into the penile tissue, producing an erection.

PDE5 is the enzyme that breaks down cGMP. By selectively inhibiting PDE5, sildenafil prolongs the action of cGMP, enhancing and sustaining penile blood flow when sexual stimulation occurs. The drug does not cause an erection on its own; sexual arousal is still required.

Key pharmacologic points:

  • Onset of action: typically 30-60 minutes after oral intake.
  • Peak effect: 1-2 hours.
  • Duration: up to 4-6 hours, varying with dose and individual metabolism.
  • Bioavailability: approximately 40 % when taken on an empty stomach; high-fat meals can delay absorption.
  • Metabolism: primarily hepatic via CYP3A4 and CYP2C9 enzymes; metabolites are excreted in urine.

Conditions Treated by Caverta

Caverta is approved by the MHRA for the diagnosis and treatment of erectile dysfunction in adult men. The indication covers men who experience difficulty achieving or maintaining an erection sufficient for satisfactory sexual performance. The medication is intended for use on an as-needed basis rather than continuous daily therapy.

Sildenafil, the active component, is also approved under a different brand (Revatio) for pulmonary arterial hypertension (PAH). However, Caverta is not marketed for PAH in the UK; any use for that condition would be off-label and must be guided by a specialist.

Typical patients include:

  • Men aged 18 years and older with documented ED.
  • Individuals whose ED is associated with diabetes, cardiovascular disease, or postoperative status, provided no contraindications exist.

Off-Label and Investigational Applications

Evidence-Based Off-Label Uses

  • Pulmonary arterial hypertension (PAH): Sildenafil improves exercise capacity and hemodynamics in PAH patients. This use is formally approved for the Revatio formulation, not for Caverta. Off-label prescribing for PAH requires specialist supervision and is not covered by the Caverta product label.

  • Benign prostatic hyperplasia (BPH) symptom relief: Small studies suggest low-dose sildenafil may improve lower urinary tract symptoms, but evidence remains limited. Use for BPH is not approved and should only be considered within a clinical trial or specialist setting.

All off-label applications must be supervised by a qualified healthcare provider, with a thorough risk-benefit assessment.

Who Should and Should Not Use Caverta?

Absolute Contraindications

  • Known hypersensitivity to sildenafil or any tablet excipients.
  • Concurrent use of nitrates (e.g., nitroglycerin, isosorbide dinitrate) in any form, due to risk of severe hypotension.
  • Use with guanylate cyclase stimulators (e.g., riociguat) for PAH.

Relative Contraindications

  • Cardiovascular disease: Unstable angina, recent myocardial infarction (< 6 weeks), severe uncontrolled hypertension (systolic > 180 mmHg or diastolic > 110 mmHg).
  • Severe hepatic impairment (Child-Pugh C) - dose reduction may be required.
  • Severe renal impairment (CrCl < 30 mL/min) - consider lower starting dose.
  • Use in pregnant or breastfeeding men is not applicable, but women should avoid handling crushed tablets without gloves due to potential absorption.

Special Populations

  • Elderly men: May be more sensitive to hypotensive effects; start at 50 mg and monitor tolerability.
  • Patients on alpha-blockers (e.g., for benign prostatic hyperplasia): Monitor for additive blood pressure lowering; dose adjustment may be necessary.
  • Patients with hereditary retinal disorders (e.g., retinitis pigmentosa) - caution due to rare reports of vision changes.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Headache - often mild, improves with continued use.
  • Flushed skin (especially face and neck).
  • Indigestion or dyspepsia - can be minimized by taking the pill with water, not immediately after a large fatty meal.
  • Nasal congestion or runny nose.
  • Visual disturbances (e.g., blue-tinted vision) - generally transient.

Serious Adverse Events

  • Sudden loss of vision (non-arteritic anterior ischemic optic neuropathy - NAION). Immediate ophthalmologic evaluation is required.
  • Sudden hearing loss - rare; discontinue and seek urgent care.
  • Priapism (erection lasting > 4 hours) - seek emergency treatment to prevent permanent damage.
  • Severe hypotension - particularly when combined with nitrates or potent vasodilators.

Drug Interactions

  • Major: Nitrates (any formulation), guanylate cyclase stimulators.
  • Moderate: Alpha-blockers, CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) - may increase sildenafil plasma levels, necessitating dose reduction.
  • CYP inducers (e.g., rifampicin, carbamazepine) - may reduce efficacy; consider alternative therapy.

Food and Lifestyle Interactions

  • High-fat meals can delay the onset of action by up to 2 hours.
  • Alcohol in moderate amounts may increase the risk of side effects such as dizziness and hypotension; excess consumption should be avoided.
  • Grapefruit juice may potentiate sildenafil levels; limit intake.
  • Operating machinery: Most men can safely drive after taking Caverta, but be cautious if experiencing dizziness or visual changes.

How to Take Caverta

  • Standard dosing: Start with 50 mg taken as needed about 1 hour before sexual activity. If well tolerated and not sufficiently effective, the dose may be increased to 100 mg. The maximum recommended frequency is once daily.
  • Administration: Swallow the tablet whole with a glass of water. The pill may be taken with or without food, but avoid a large fatty meal immediately before dosing.
  • Special populations: For men over 65, or those with moderate hepatic/renal impairment, a starting dose of 50 mg (or lower, e.g., 25 mg if available) is advisable; dose adjustments should be guided by the prescriber.
  • Missed dose: If you forget to take a dose and the next planned sexual activity is more than 24 hours away, simply skip the missed dose. Do not double up.
  • Overdose: Symptoms may include severe dizziness, fainting, prolonged erection, or chest pain. Seek immediate medical attention; there is no specific antidote, and treatment is supportive.
  • Discontinuation: No tapering is required. Stop use if adverse effects are intolerable or if a healthcare professional advises cessation.

Monitoring and Follow-Up

Routine laboratory monitoring is not required for most men using Caverta. However, clinicians may consider:

  • Blood pressure checks before initiating therapy, especially in patients with known hypertension or cardiovascular disease.
  • Cardiovascular assessment for men with significant cardiac risk factors who plan to engage in sexual activity that may be physically demanding.
  • Renal or hepatic function tests if underlying disease exists or if the patient is taking interacting medications that affect metabolism.

Patients should contact their prescriber if they experience persistent visual loss, prolonged erection, severe chest pain, or any new cardiovascular symptoms.

Storage and Handling

  • Store Caverta tablets at room temperature (15-25 °C), away from excess moisture and direct sunlight.
  • Keep the bottle tightly closed and out of reach of children.
  • Do not use the medication after the printed expiry date.
  • Dispose of unused tablets according to local pharmacy take-back programmes or follow NHS guidance for safe disposal.

Medication-Specific Glossary

Phosphodiesterase-type 5 (PDE5) inhibitor
A drug class that blocks the PDE5 enzyme, preventing the breakdown of cGMP and thereby enhancing penile blood flow during sexual stimulation.
cGMP (cyclic guanosine monophosphate)
A second messenger molecule that relaxes smooth muscle in the corpus cavernosum, facilitating erection.
Non-arteritic anterior ischemic optic neuropathy (NAION)
A rare, sudden loss of vision due to impaired blood flow to the optic nerve; reported as a serious but uncommon adverse event with PDE5 inhibitors.
Priapism
An erection lasting longer than four hours that is unrelated to sexual stimulation and may cause permanent tissue damage if untreated.

Medical Disclaimer

This article provides educational information about Caverta and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Caverta is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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