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Voltaren SR

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Voltaren SR (Diclofenac Sodium) is a sustained-release non-steroidal anti-inflammatory drug. This formulation provides a gradual release of medication to manage chronic pain and inflammation throughout the day. It is especially effective for adults requiring continuous relief from arthritic symptoms and joint discomfort.


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In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Diclofenac Sodium
Reference Brand
Voltarol SR
Manufacturer
Novartis
Product Form
Modified-release tablet
Regulatory Classification
Rx
Primary Category
Pain Relief
Product Category
Non-steroidal anti-inflammatory drugs (NSAIDs), Acetic acid derivatives
Pharmacological Class
NSAID
Manufacturer Description
An anti-inflammatory painkiller used for long-term relief from joint and muscle pain and inflammation.
Mechanism of Action
Diclofenac blocks enzyme actions (COX-1 and COX-2) that produce prostaglandins, which are chemicals in the body that signal pain and cause inflammation. By reducing these, it eases pain and swelling.
Route of Administration
Oral
Onset Time
1-2 hours
Duration
12-24 hours
Contraindications
Stomach ulcers, Severe heart failure, Last three months of pregnancy, Aspirin-induced asthma
Severe Adverse Events
Black or bloody stools, Chest pain, Jaundice, Severe allergic reactions
Common Side Effects
Stomach ache, Heartburn, Dizziness, Headache
Uncommon Side Effects
Nausea, Diarrhoea, Rash, Wind
Drug Interactions
Warfarin, Other NSAIDs, Aspirin, Lithium
Pregnancy Safety Warnings
Avoid, especially in the third trimester.
Age Restrictions
Not recommended for children under 14-18 depending on specific product
Storage Guidelines
Keep in the original packaging at room temperature.
Related Products
Ibuprofen, Naproxen, Dicloflex

Voltaren SR FAQ

Can I take Voltaren SR with other painkillers?

Combining Voltaren SR with other NSAIDs or high-dose aspirin increases the risk of gastrointestinal bleeding and should be avoided unless specifically directed by a prescriber. If additional analgesia is needed, acetaminophen (paracetamol) is generally considered safer, but you should discuss this with your healthcare provider.

Does Voltaren SR affect blood pressure?

NSAIDs, including diclofenac, can cause fluid retention and may raise blood pressure in susceptible individuals. Regular monitoring is advisable for patients with hypertension or those taking antihypertensive medication.

What should I do if I miss a dose while traveling across time zones?

Take the missed tablet as soon as you remember, provided it is at least 12 hours before the next scheduled dose. Do not double the dose to catch up. Adjust the timing to maintain a roughly 24-hour interval thereafter.

Are there any special considerations for pilots or airline crew?

Pilots should be aware that dizziness or visual disturbances from diclofenac could impair flight performance. Aviation medical regulations typically require reporting of any medication that may affect cognition or alertness; consult the relevant aviation authority.

How does Voltaren SR compare with ibuprofen for osteoarthritis?

Both are NSAIDs, but diclofenac (Voltaren SR) is often prescribed at a lower daily dose due to its potency. Clinical guidelines suggest individual response and tolerability guide the choice; no single drug is universally superior.

Is it safe to take Voltaren SR during a marathon or intense exercise?

Intense exercise can increase the risk of dehydration and renal strain. Since NSAIDs may further affect kidney function, ensure adequate hydration and discuss continued use with a sports medicine professional.

What inactive ingredients are in Voltaren SR tablets?

The exact excipient list varies by manufacturer and region. Common inactive components may include microcrystalline cellulose, lactose, and magnesium stearate. If you have known excipient allergies, review the product label or ask your pharmacist.

Can Voltaren SR be used for dental pain after a tooth extraction?

While diclofenac can provide analgesia for dental pain, it is not the first-line recommendation for post-extraction discomfort in the UK. Dentists often prescribe paracetamol or a short course of ibuprofen; consult your dentist for specific advice.

Do I need a special prescription for a repeat supply?

Voltaren SR is a prescription-only medicine. In the UK, repeat prescriptions are usually arranged by the prescriber after a review of treatment efficacy and safety. Automated repeat dispensing is not permitted without a clinician’s approval.

How long can I safely stay on Voltaren SR for chronic arthritis?

Long-term NSAID therapy should be periodically reassessed. Guidelines suggest limiting continuous use to the lowest effective dose and conducting regular monitoring of renal, hepatic, and cardiovascular status. Individual duration depends on disease severity and risk factors.

What is Voltaren SR?

Voltaren SR is a brand-name medication that contains diclofenac sodium as its active ingredient. It belongs to the pain-relief therapeutic class, specifically the non-steroidal anti-inflammatory drug (NSAID) group. Voltaren SR is supplied as a sustained-release (SR) pill in a 100 mg strength. In the United Kingdom it is classified as a prescription-only medicine (POM) and is regulated by the Medicines and Healthcare products Regulatory Agency (MHRA). The formulation is designed to release diclofenac gradually over several hours, providing prolonged symptom control compared with immediate-release tablets.

How Voltaren SR Works in the Body

Diclofenac sodium belongs to the NSAID family. Its primary mechanism is the inhibition of cyclooxygenase (COX) enzymes, particularly COX-2, which are responsible for converting arachidonic acid into prostaglandins. Prostaglandins mediate pain, inflammation, and fever. By reducing prostaglandin synthesis, diclofenac lowers the sensitivity of nerve endings to pain signals and diminishes inflammation in affected tissues.

  • Onset of action: Analgesic effects can be felt within 30-60 minutes after the tablet is swallowed.
  • Peak effect: Because the formulation is sustained-release, peak plasma concentrations are typically reached 6-8 hours after ingestion.
  • Duration: Therapeutic concentrations are maintained for up to 24 hours, supporting once-daily dosing.

The sustained-release matrix allows the drug to be absorbed more slowly, which can reduce gastrointestinal irritation compared with immediate-release NSAIDs, although the overall risk profile remains similar.

Conditions Treated by Voltaren SR

Voltaren SR is authorised by the MHRA for the following indications:

  • Osteoarthritis - relief of pain and improvement in joint function.
  • Rheumatoid arthritis - reduction of joint pain, swelling, and stiffness.
  • Ankylosing spondylitis - alleviation of spinal pain and inflammation.
  • Acute musculoskeletal pain - such as pain from sprains, strains, or soft-tissue injuries.

These indications are based on clinical trials that demonstrated the drug’s efficacy in reducing pain scores and improving mobility in adult patients. The medication is intended for adult use; it is not recommended for routine use in children or adolescents.

Evidence-Based Off-Label Uses

Some clinical reports have explored diclofenac’s utility beyond its approved indications, for example in the management of migraine attacks or post-operative pain. These uses are not approved by the MHRA and should only be considered under specialist supervision, weighing the potential benefits against known cardiovascular and gastrointestinal risks.

Disclaimer: Off-label use requires medical supervision and an individualized risk assessment.

Who Should (Not) Use Voltaren SR?

Absolute Contra-indications

  • Known hypersensitivity to diclofenac, other NSAIDs, or any excipients in the tablet.
  • History of peptic ulcer disease with active bleeding or perforation.
  • Severe heart failure (NYHA class III or IV).
  • Third-trimester pregnancy (risk of premature closure of the fetal ductus arteriosus).
  • Use in patients receiving reversible cyclo-oxygenase-2 (COX-2) inhibitors combined with diclofenac.

Relative Contra-indications

  • Mild to moderate renal impairment (dose adjustment may be required).
  • Hepatic dysfunction (monitor liver enzymes).
  • Elderly patients (greater susceptibility to GI and renal adverse effects).
  • Concomitant use of low-dose aspirin, other NSAIDs, or anticoagulants (increased bleeding risk).

Special Populations

  • Pregnancy: Avoid except when clearly needed and after specialist advice; contraindicated after 30 weeks gestation.
  • Breastfeeding: Diclofenac is excreted in breast milk; use only if the benefit outweighs the risk.
  • Pediatrics: Not indicated for routine use in children under 16 years.

Safety Profile and Interactions

Common Side Effects

  • Gastro-intestinal: Dyspepsia, abdominal pain, nausea.
  • Central nervous system: Headache, dizziness, mild fatigue.
  • Dermatologic: Rash or mild skin irritation.

These effects are generally transient and may be mitigated by taking the tablet with food.

Serious Adverse Events

  • Upper gastrointestinal bleeding, ulceration, or perforation.
  • Cardiovascular events such as myocardial infarction or stroke, particularly with long-term use.
  • Renal toxicity - acute kidney injury or worsening of chronic renal disease.
  • Hepatotoxicity - elevated transaminases, jaundice.
  • Severe skin reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis).

Patients experiencing sudden abdominal pain, vomiting blood, black stools, chest pain, or severe skin rash should seek immediate medical attention.

Drug Interactions

  • Anticoagulants (e.g., warfarin): Increased risk of bleeding; monitor INR closely.
  • Other NSAIDs or aspirin: Additive gastrointestinal toxicity.
  • ACE inhibitors / ARBs / Diuretics: May reduce renal perfusion; monitor renal function.
  • Lithium: Diclofenac can raise lithium levels; adjust dosage as needed.
  • Methotrexate: Reduced clearance may lead to toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): Higher bleeding risk.

Food and Lifestyle Interactions

  • Take with food or a glass of milk to lessen gastrointestinal irritation.
  • Alcohol can potentiate stomach lining damage; limit intake.
  • Driving: If dizziness occurs, avoid operating machinery or driving.
  • Sunlight: No specific photosensitivity reported, but general skin protection is advisable.

If detailed interaction data for Voltaren SR are limited, patients should inform their healthcare provider of all medicines, supplements, and herbal products before starting therapy.

How to Take Voltaren SR

  • Standard dosing: One 100 mg sustained-release tablet taken once daily, preferably in the morning with food.
  • Renal impairment: In patients with creatinine clearance < 30 mL/min, the maximum daily dose should not exceed 50 mg, and therapy duration should be limited.
  • Hepatic impairment: Use the lowest effective dose and monitor liver enzymes regularly.
  • Elderly: Start with a single 100 mg tablet; assess tolerance before continuing.
  • Administration: Swallow whole; do not split, chew, or crush the tablet, as this would destroy the sustained-release matrix.
  • Missed dose: If a dose is missed and the next scheduled dose is >12 hours away, take the missed tablet. Do not double up.
  • Overdose: Symptoms may include nausea, vomiting, abdominal pain, dizziness, or drowsiness. Seek urgent medical care; treatment is mainly supportive (e.g., activated charcoal, intravenous fluids).
  • Discontinuation: No tapering is required for short-term use. For long-term therapy, discuss with a prescriber to assess the need for gradual withdrawal, especially if cardiovascular risk is a concern.

Monitoring and Follow-Up

  • Baseline assessments: Blood pressure, renal function (serum creatinine, eGFR), liver enzymes (ALT, AST), and complete blood count.
  • Periodic monitoring: Every 3-6 months for patients on long-term therapy, or sooner if symptoms of toxicity arise.
  • Clinical review: Evaluate pain control, functional improvement, and any adverse effects at each visit.
  • When to contact a provider: New onset of severe abdominal pain, unexplained bruising, swelling of the legs, sudden shortness of breath, or signs of liver dysfunction (jaundice, dark urine).

Storage and Handling

  • Store tablets at room temperature (below 30 °C) in a dry place, away from direct sunlight and moisture.
  • Keep the container tightly closed and out of reach of children.
  • Do not use the medication after the expiry date printed on the pack.
  • Dispose of unused tablets according to local pharmacy take-back schemes or follow the “discard as household waste” instructions if a take-back program is unavailable.

Medication-Specific Glossary

Cyclooxygenase (COX)
Enzymes (COX-1 and COX-2) that convert arachidonic acid into prostaglandins, which mediate inflammation, pain, and fever.
Prostaglandins
Lipid compounds that promote inflammation, pain sensation, and fever; reduction of their production underlies NSAID analgesic effects.
Sustained Release
A pharmaceutical formulation that releases the active ingredient gradually over an extended period, allowing once-daily dosing.
Gastrointestinal Bleeding
Loss of blood from the digestive tract, which can present as vomiting blood, black tarry stools, or anemia; a known risk of NSAIDs.
NSAID
Non-steroidal anti-inflammatory drug, a class of medications that reduce inflammation and pain by inhibiting COX enzymes.

Medical Disclaimer

This article provides educational information about Voltaren SR and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Voltaren SR is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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